Mitochondrical Gene Therapy

Khan, Shaharyar M.

Mitochondrical Gene Therapy 903 views

Author

Khan, Shaharyar M., Department of Medicine, University of Virginia

Advisors

Bayliss, Douglas , Department of Medicine , University of Virginia
Lee, Kevin , Department of Neuroscience , University of Virginia

Abstract

Many diseases arise from mutations in mitochondrial DNA (mtDNA). These conditions typically affect non-mitotic tissues (brain, retina, muscle) and are largely untreatable. Evidence is accumulating for mtDNA abnormalities in diseases such as Alzheimer's, Parkinson's and type II diabetes. Research and treatment of these conditions is hampered by lack of methods for manipulation of the mitochondrial genome in situ. This dissertation presents the development of technologies and the insights they reveal for delivery of the entire human mitochondrial genome into cells and animals opening the way for the treatment of diseases arising from defects in mitochondrial DNA.

Note: Abstract extracted from PDF text

Degree

PHD (Doctor of Philosophy)

Language

English

Rights

Issued Date

2006-06-01

Persistent Link

https://doi.org/10.18130/V3DF8J

Suggested Citation

Khan, Shaharyar M.. Mitochondrical Gene Therapy. University of Virginia, Department of Medicine, PHD (Doctor of Philosophy), 2006-06-01, https://doi.org/10.18130/V3DF8J.

Files

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