Online Archive of University of Virginia Scholarship
Protocols to Improve the Electrophysiological Maturity of iPSC-Derived Neurons312 views
Author
Harbom, Lise, Neuroscience - School of Medicine, University of Virginia
Advisors
Beenhakker, Mark, MD-PHAR Pharmacology, University of Virginia
McConnell, Michael, MD-BIOC Biochem/Mole Genetics, University of Virginia
Abstract
Achieving functional maturity in iPSC-derived neurons is an ongoing goal in the field. In order to achieve this goal, it is likely necessary to evaluate the human development of electrical activity in vivo and the factors that affect the successful wiring of neural networks. The work presented in this dissertation seeks to evaluate how altering a few of these factors via culture conditions during neuronal maturation contributes to long-term electrophysiological maturity.
Harbom, Lise. Protocols to Improve the Electrophysiological Maturity of iPSC-Derived Neurons. University of Virginia, Neuroscience - School of Medicine, PHD (Doctor of Philosophy), 2019-05-05, https://doi.org/10.18130/v3-jc5b-ht66.
