Investigation of Chiral Tag Rotational Spectroscopy for Absolute Configuration Determination

Rotational Spectroscopy has seen many improvements since the 1970s, from increases in sensitivity, to decreases in sample consumption and time. While it has seen widespread use in diastereomer analysis, it has faced inherent challenges in enantiomer detection. For this reason, techniques are being developed that would allow for the use of rotational spectroscopy in enantiomer analysis. In this thesis, the use of a chiral tagging method was investigated for its ability to use rotational spectroscopy for determining absolute configuration. Two test cases are presented: the determination of the absolute configuration of a bicyclic monoterpene ketone enantiomer, and the identification of a sesquiterpene alcohol enantiomer. While these cases are simple compounds for test cases, they are important tests for the effectiveness of using
rotational spectroscopy for absolute configuration determination