Dysregulated Innate Immune Signaling as a Driver of Impaired Neurodevelopment

This thesis is the cumulation of my studies into how the innate immune system affects neurodevelopment. Throughout my graduate career, I have investigated both how lack of innate immune signaling and how overactive immune signaling are detrimental to neurodevelopment. As with most biological systems, neurodevelopment requires a careful balance of immune signaling in order to establish and maintain properly formed connections and functions.