A Novel Role for Signal Transducer and Activator of Transcription 5b (STAT5b) in b1 Integrin-Medicated Breast Cancer Cell Migration
Author:
Bernaciak, Teresa Marie, Department of Microbiology, University of Virginia
Bernaciak, Teresa Marie, Department of Microbiology, University of Virginia
Advisors:
Silva, Corinne, Department of Microbiology, University of Virginia
Parsons, Sally, Department of Microbiology, University of Virginia
Parsons, Tom, Department of Microbiology, University of Virginia
Brautigan, David, Department of Microbiology, University of Virginia
Mayo, Marty, Department of Biochemistry and Molecular Genetics, University of Virginia
Guise, Theresa
Silva, Corinne, Department of Microbiology, University of Virginia
Parsons, Sally, Department of Microbiology, University of Virginia
Parsons, Tom, Department of Microbiology, University of Virginia
Brautigan, David, Department of Microbiology, University of Virginia
Mayo, Marty, Department of Biochemistry and Molecular Genetics, University of Virginia
Guise, Theresa
Abstract:
Signal transducer and activator of transcription Sb (STAT5b) is a transcription factor which promotes growth and survival of a number of cancers, including breast cancer. Additionally, STAT5b has been implicated in the invasion of metastatic prostate cancer cells. However, its requirement for breast cancer cell migration and invasion has not been determined. The objective of this work was to determine whether there is a role for STAT5b in breast cancer cell migration.
Note: Abstract extracted from PDF file via OCR
Degree:
PHD (Doctor of Philosophy)
PHD (Doctor of Philosophy)
Language:
English
English
Rights:
All rights reserved (no additional license for public reuse)
All rights reserved (no additional license for public reuse)
Issued Date:
2009/08/01
2009/08/01
