Biochemical Characterization of DNA Damaging Agents
Author:
Zaleski II, Paul Allen, Department of Chemistry, University of Virginia
Zaleski II, Paul Allen, Department of Chemistry, University of Virginia
Advisors:
Hecht, Sidney, Department of Chemistry, University of Virginia
Cafiso, David, Department of Chemistry, University of Virginia
Chruma, Jason
Sundberg, Richard, Department of Chemistry, University of Virginia
Hockensmith, Joel, Department of Biochemistry and Molecular Genetics, University of Virginia
Hecht, Sidney, Department of Chemistry, University of Virginia
Cafiso, David, Department of Chemistry, University of Virginia
Chruma, Jason
Sundberg, Richard, Department of Chemistry, University of Virginia
Hockensmith, Joel, Department of Biochemistry and Molecular Genetics, University of Virginia
Abstract:
This dissertation describes the biochemical characterization of agents that damage DNA. Compounds of this type can have significant clinical value as chemotherapic agents due to their ability to mediate DNA strand cleavage. A central theme in the Hecht laboratory is to investigate the various interactions between DNA damaging agents and DNA to further understand their mechanisms of action.
Note: Abstract extracted from PDF text
Degree:
PHD (Doctor of Philosophy)
PHD (Doctor of Philosophy)
Language:
English
English
Rights:
All rights reserved (no additional license for public reuse)
All rights reserved (no additional license for public reuse)
Issued Date:
2011/08/01
2011/08/01
