Biochemical Characterization of DNA Damaging Agents

Zaleski II, Paul Allen

Biochemical Characterization of DNA Damaging Agents 413 views

Author

Zaleski II, Paul Allen, Department of Chemistry, University of Virginia

Advisors

Hecht, Sidney , Department of Chemistry , University of Virginia
Cafiso, David , Department of Chemistry , University of Virginia
Chruma, Jason
Sundberg, Richard , Department of Chemistry , University of Virginia
Hockensmith, Joel , Department of Biochemistry and Molecular Genetics , University of Virginia

Abstract

This dissertation describes the biochemical characterization of agents that damage DNA. Compounds of this type can have significant clinical value as chemotherapic agents due to their ability to mediate DNA strand cleavage. A central theme in the Hecht laboratory is to investigate the various interactions between DNA damaging agents and DNA to further understand their mechanisms of action.

Note: Abstract extracted from PDF text

Degree

PHD (Doctor of Philosophy)

Language

English

Rights

Issued Date

2011-08-01

Persistent Link

https://doi.org/10.18130/V3RK1C

Suggested Citation

Zaleski II, Paul Allen. Biochemical Characterization of DNA Damaging Agents. University of Virginia, Department of Chemistry, PHD (Doctor of Philosophy), 2011-08-01, https://doi.org/10.18130/V3RK1C.

Files

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