DsbA2 Catalyzes Disulfide Bond Formation and Is Essential for Virulence in Legionella pneumophila

Jameson-Lee, Max

DsbA2 Catalyzes Disulfide Bond Formation and Is Essential for Virulence in Legionella pneumophila 650 views

Author

Jameson-Lee, Max, Department of Microbiology, Immunology, and Cancer Biology, University of Virginia

Advisors

Hoffman, Paul , Department of Microbiology, Immunology, and Cancer Biology , University of Virginia

Abstract

Chapter 1: Literature Review 1.1. Introduction 1 1.2. The Family Legionellaccae 1 1.3. Taxonomy 2 1.4. Diseases Caused by Legionella 3 1.5. Diagnosis 3 1.6. Legionella Growth Media 3 1.7. L. pneumophila, Protozoa, and Human Transmission 4 1.8. Developmental Cycle 5 1.9. Factors Controlling Developmental Cycle 7 1.10. Replication of Legionella pneumophila in Eukaryotic Cells 11 1.11. Dot/Icm 12 1.11.1. Dot/Icm Effectors 12 1.11.2. Dot/Icm Components 13 1.11.3. Assembly of T4SS 16 iv 1.12. Disulfide Bond Proteins 16 1.13. Dsb System Overview 18 1.14. Basic Principles: TRX Proteins & Regulators 18 1.15. DsbA/DsbB 19 1.16. DsbC/DsbG/DsbD 21 1.17. Dsb Machinery in Other Bacteria 22 1.18. DsbA Contribution to Virulence 23 1.19. Dsb in Legionella 25 1.20.

Note: Abstract extracted from PDF text

Degree

PHD (Doctor of Philosophy)

Language

English

Rights

Issued Date

2012-05-01

Persistent Link

https://doi.org/10.18130/V3HZ3R

Suggested Citation

Jameson-Lee, Max. DsbA2 Catalyzes Disulfide Bond Formation and Is Essential for Virulence in Legionella pneumophila. University of Virginia, Department of Microbiology, Immunology, and Cancer Biology, PHD (Doctor of Philosophy), 2012-05-01, https://doi.org/10.18130/V3HZ3R.

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