Online Archive of University of Virginia Scholarship
Early-phase Dose-finding Designs for Bivariate Outcomes433 views
Author
Tait, Christopher, Statistics - Graduate School of Arts and Sciences, University of Virginia
Advisors
Wages, Nolan, PBHS Public Health Sciences Admin, University of Virginia
Abstract
In dose-finding trials of chemotherapeutic agents, the goal of identifying the maximum tolerated dose is usually determined by considering information on toxicity only, with the assumption that the highest safe dose also provides the most promising outlook for efficacy. Trials of molecularly targeted agents challenge accepted dose-finding methods because minimal toxicity may arise over all doses under consideration and higher doses may not result in greater response. A class of new early-phase method for trials investigating targeted agents will be presented. Simulation results and theoretical properties are provided to illustrate the operating characteristics of the designs.
Tait, Christopher. Early-phase Dose-finding Designs for Bivariate Outcomes. University of Virginia, Statistics - Graduate School of Arts and Sciences, PHD (Doctor of Philosophy), 2014-11-11, https://doi.org/10.18130/V3MG0Q.
