Microfluidic Integration of a Pancreatic Tumor Microenvironment to Study the Effects of Chemotherapeutics; Unconvinced Patients: Resistance to Care among Patients with Depression

Tate, Steven, School of Engineering and Applied Science, University of Virginia
Swami, Nathan, EN-Elec/Computer Engr Dept, University of Virginia
Norton, Peter, EN-Engineering and Society, University of Virginia

Physical and mental wellbeing are the interdependent essentials of human health.
In 2020, approximately 600,000 Americans died of cancerous diseases. With a simulated pancreatic tumor, drugs could be tested in vivo apart from human clinical trials. A prototype novel microfluidic device for the controlled delivery of variable concentrations of drugs to a tumor microenvironment was developed and tested. The device may serve as a useful biomimetic drug interrogation platform. The prototype was shown to have a high efficacy and further study will allow for the integration into the tumor microenvironment.
Many clinically depressed persons do not seek treatment or decline to follow prescribed care. Avoidance of care or treatment is often due to depressed persons’ low assessment of their self-efficacy Education, destigmatization, patient-clinician collaboration, patient support systems, and healthcare regulation is necessary.

BS (Bachelor of Science)
Microfluidics, Depression, Cancer, Patient-Clinician Collaboration, Hydrodynamic Confinement Flow

School of Engineering and Applied Science
Bachelor of Science in Biomedical Engineering
Technical Advisor: Nathan Swami, Ph.D.
STS Advisor: Peter Norton
Technical Team Members: Steven Tate

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