Tumor-associated HLA-A*0201-restricted Phosphopeptides as Candidates for Cancer Immunotherapy
Author:
Obeng, Rebecca Cynthia, Department of Microbiology, Immunology, and Cancer Biology, University of Virginia
Obeng, Rebecca Cynthia, Department of Microbiology, Immunology, and Cancer Biology, University of Virginia
Advisors:
Engelhard, Victor H., Department of Microbiology, Immunology, and Cancer Biology, University of Virginia
Bouton, Amy, Department of Microbiology, University of Virginia
Brautigan, David, Department of Microbiology, University of Virginia
Bender, Timothy, Department of Microbiology, University of Virginia
Bullock, Timothy, Department of Pathology, University of Virginia
Engelhard, Victor H., Department of Microbiology, Immunology, and Cancer Biology, University of Virginia
Bouton, Amy, Department of Microbiology, University of Virginia
Brautigan, David, Department of Microbiology, University of Virginia
Bender, Timothy, Department of Microbiology, University of Virginia
Bullock, Timothy, Department of Pathology, University of Virginia
Abstract:
Dysregulated phosphorylation of proteins by constitutively active kinases in tumors generates a pool of malignancy-relevant phosphorylated peptides that are presented by MHC class I and II on tumor cells. These phosphopeptides can be recognized by CD8 and CD4 T cells and represent attractive targets for immunotherapy.
Note: Abstract extracted from PDF text
Degree:
PHD (Doctor of Philosophy)
PHD (Doctor of Philosophy)
Language:
English
English
Rights:
All rights reserved (no additional license for public reuse)
All rights reserved (no additional license for public reuse)
Issued Date:
2011/12/01
2011/12/01
